Predictive value of maternal C-reactive protein for detection of histological chorioamnionitis in women with prelabor rupture of membranes

  • Dr. Animesh Naskar Assistant Professor, Department of Gynecology and Obstetrics, R.G. Kar Medical College & Hospital, 1 Khudiram Bose Sarani, Kolkata, West Bengal, India
  • Dr. Somnath Ghosh Ex-Medical Officer, Department of Pathology, R.G. Kar Medical College & Hospital, 1 Khudiram Bose Sarani, Kolkata, West Bengal, India
Keywords: Chorioamnionitis, C-reactive protein, Predictive value, Prelabor rupture of membrane

Abstract

Introduction: Chorioamnionitis can be considered as an unwanted aftermath of PROM and is capable of causing considerable perinatal morbidity and mortality. It has been a focus of interest in many studies. The ability to predict histological chorioamnionitis is a high priority for Obstetricians managing women with PROM at or after 34 weeks. During the last three decades, CRP has been a useful marker of chorioamnionitis and its dreaded sequel.

Materials and Methods: With a specific objective to assess the predictive value of maternal CRP in patients with documented histological chorioamnionitis, 80 patients with high CRP value (>10mg/l) with PROM constituted the study group, against a matched control of 84 patients with low CRP value (<10 mg/l) in our study conducted in a tertiary care center in India. Labor process and management of patients were noted. Follow up was done for the mode of delivery, maternal and neonatal morbidity.

Results: Significant correlation was found between high CRP (>10mg/l) and histologically proven chorioamnionitis with a sensitivity of 93%, specificity 80%, positive predictive value 75%, and P < 0.0001. Also there is significant correlation between high CRP (>10mg/l) and maternal and neonatal morbidity.

Conclusion: CRP is a significant relevant predictor of histological chorioamnionitis, maternal and neonatal morbidity.

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References

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Predictive value of maternal C-reactive protein for detection of histological chorioamnionitis in women with prelabor rupture of membranes
CITATION
DOI: 10.17511/joog.2019.i02.01
Published: 2019-10-16
How to Cite
Naskar, A., & Ghosh, S. (2019). Predictive value of maternal C-reactive protein for detection of histological chorioamnionitis in women with prelabor rupture of membranes. Obs Gyne Review: Journal of Obstetric and Gynecology, 5(2), 83-92. https://doi.org/10.17511/joog.2019.i02.01
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Original Article