A rare case of Weil’s disease in pregnancy
Abstract
Weil’s disease in pregnancy is an uncommon entity. It is a severe form of leptospirosis with the presence of jaundice and renal damage. Leptospirosis is a major zoonotic disease and human infection results from accidental contact with the environment contaminated with the urine of the carrier. The infection ranges from a mild flu like illness to a serious, sometimes fatal disease. Infection in pregnancy may be grave leading to maternal and fetal morbidity and mortality unless treated early. Moreover in pregnancy, the presentation may mimic other viral, bacterial and parasitic infections, Acute Fatty Liver in Pregnancy (AFLP), Pregnancy Induced Hypertension (PIH) and HELLP (Hemolysis, Elevated Liver Enzymes, Low Platelet) syndrome and owing to this unusual presentation, leptospirosis is often misdiagnosed and under-reported.
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References
2. Levett PN. Leptospirosis. Clin Microbiol Rev. 2001 Apr;14(2):296-326. DOI:10.1128/CMR.14.2.296-326.2001.[pubmed]
3. Everett ED, Calderwood SB. Microbiology, epidemiology, clinical manifestations, and diagnosis of leptospirosis. UpToDate [online][Accessed September 6, 2011]. Available at: www.uptodate.com .
4. Farr RW. Leptospirosis. Clin Infect Dis. 1995 Jul;21(1):1-6; quiz 7-8.[pubmed]
5. Chedraui PA, San Miguel G. A case of leptospirosis and pregnancy. Arch Gynecol Obstet. 2003 Nov;269(1):53-4. Epub 2002 Oct 2. DOI:10.1007/s00404-002-0415-3.[pubmed]
6. World Health Organization-International Leptospirosis Society (2003) Human leptospirosis: Guidance for diagnosis, surveillance and control. http://www.leptonet.net/assets/images/LeptoGuidelines_ Print_version_19May03.pdf Accessed 6 March 2010.
7. Sethi S, Sharma N, Kakkar N, et al. Increasing trends of leptospirosis in northern India: a clinico-epidemiological study. PLoSNegl Trop Dis. 2010 Jan 12;4(1):e579. doi: 10.1371/journal.pntd.0000579.[pubmed]
8. Prasanthie HMM, De Silva KHPUD. A rare complication of leptospirosis: acute pancreatitis. Galle Med J 2008;13:69–70.
9. Carles G, Montoya E, Joly F, et al. [Leptospirosis and pregnancy. Eleven cases in French Guyana]. J GynecolObstetBiolReprod (Paris). 1995;24(4):418-21.[pubmed]
10. Shaked Y, Shpilberg O, Samra D, et al. Leptospirosis in pregnancy and its effect on the fetus: case report and review. Clin Infect Dis. 1993 Aug;17(2):241-3.[pubmed]
11. Bolin CA, Koellner P. Human-to-human transmission of Leptospira interrogans by milk. J Infect Dis. 1988 Jul;158(1):246-7.[pubmed]
12. Chung HL, Tsao WC, Mo PS, et al. Transplacental or Congenital Infection of Leptospirosis. Clinical and Experimental Observations. Chin Med J. 1963 Dec;82:777-82.
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