To study the correlation of serum lactate dehydrogenase (LDH) levels in women with preeclampsia on maternal and perinatal outcome
Abstract
Introduction: Pre-eclampsia is a multi-system disorder of unknown etiology and a major cause of maternaland perinatal complications. LDH is an intracellular enzyme and is increased when there isincreased cell death. As pre-eclampsia leads to cellular death, so LDH levels can beusedtoassesstheseverityofdisease. Aim: To study the correlation of levels of serum LDH in women with preeclampsia on maternal and perinatal outcome.
Objectives: To correlate the maternal and perinatal outcomes with serum LDH levels. To assess serum LDH as a marker for severity of preeclampsia.
Materials and Methods: A prospective comparative studywas conducted over a period of 18 months from November 2016 to April 2018 in the department of Obstetrics and Gynecology, Sri Siddhartha Medical Hospital, Tumakuru. Out of 180 women studied, 100 were normal pregnant women, 40 patients were having mild preeclampsia and 40 patients were having severe preeclampsia. The two groups and subgroups were studied based on age, gravidity, trimester, investigations, maternal and perinatal outcome, complications and follow up.
Results: Higher values of LDH were found in mild and severe preeclamptic women than those of normal pregnant women in third trimester and was statistically significant. Severe lypreec lamptic patients had increased LDH levels which in association with investigations, outcome, complications and follow up was significant.
Conclusion: LDH is a useful biochemical marker and can be considered as a supportive prognostic tool thatreflects the severity and complications of preeclampsia. Identification of high-risk patients, theirclose monitoring, and correct management may prevent these complications.
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References
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