Comparative efficacy of protein creatinine ratio and calcium creatinine ratio in determining organ dysfunction in ante-natal patients with pre-eclampsia
Aim: To evaluate the biochemical parameters in determining the severity of pre-eclampsia and compare the efficacy between protein creatinine ratio and calcium creatinine ratio in determining organ dysfunction in ante-natal women with pregnancy-induced hypertension.
Material and Methods: 150 cases of pregnancy-induced hypertension admitted in the labour room were studied in the Department of Obstetrics and Gynaecology, SRMSIMS and were divided into two groups mild and severe pre-eclampsia depending on blood pressure, clinical and biochemical parameters. Various parameters for renal function and liver function were evaluated along with fundoscopy.
Results: On the evaluation of various parameters of renal function test and liver function test, a statistically significant p-value was observed with increase in grade of pre-eclampsia. When abnormal organ functions were compared, it was observed that PCR ≥ 0.3 is associated with 85%, 75.6% and 81.25% cases of abnormal fundoscopy, deranged renal function test and deranged liver function test compared to CCR ≤ 0.04 which was associated with 77%, 78.6% and 65% cases of abnormal fundoscopy, deranged renal function test and deranged liver function test respectively.
Conclusion: The degree of derangement among biochemical parameters increases as the disease progresses. Early determination by a single test helps to predict organ involvement and correlates with disease severity.
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