The effect of prophylactic use of intravenous tranexamic acid in abdominal hysterectomy
Introduction: Hysterectomy is one of the frequently performed major gynecological surgical procedures for various uterine pathologies. The objective of this study is to assess the effect of intravenous tranexamic acid in reducing intraoperative and postoperative blood loss in women undergoing abdominal hysterectomy.
Materials and Methods: The study was a randomized double-blind study, involving a total of 120 women undergoing abdominal hysterectomy for benign etiology were randomly assigned to two groups: Group 1 (non TA): (n=60) women receiving normal saline and Group 2 (TA): (n=60) women receiving prophylactic Tranexamic Acid in 100 ml saline IV just before skin incision. The primary outcome was intraoperative, postoperative, and all blood loss estimation.
Results: Group 2 (TA) showed a great reduction in intraoperative and postoperative blood loss (blood in the intra-abdominal drain) compared with Group 1 (non TA), (P = 0.0001, 0.0001), so the overall estimated blood loss in groups 2 showed significant reduction compared with Group 1 (P = 0.0001).
Conclusion: Intravenous tranexamic acid is a safe and reliable method to help decrease blood loss during and after abdominal hysterectomy.
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